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robglen






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This message was updated on 10/17/2006 1:31:50 AM by robglen



HALF LIFE PROBLEM
posted on: 10/5/2006 5:06:20 PM

I would be grateful if anyone could answer the following problem for me.

BACKGROUND.
A medication with a half life of 58 days is taken at a dose level of
200mg per day. This medication builds up in the body over a few days to
a few weeks (it varies from person to person) to an optimum effective
level that controls the ailment. It is preferable to keep this
saturation at the lowest effective level to avoid side effects that can
occur with an unnecessarily high maintenance dosage.

THE PROBLEM
To find the maintenance dose level for a range of patients who reach
their optimum saturation after 2 weeks, 3 weeks, 4 weeks and up to 10
weeks of taking the 200mg daily dosage.

I recall calculus is probably the branch of mathematics that is required
but it is beyond me how to do this so can anyone assist.
Regards,

Robert

 



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